New ways to control disease-carrying insects
"Amitriptyline has been prescribed for more than 50 years, and we know human physiology handles it very well: physicians, pharmacists and nurses interact with it without personal protective equipment," Watts said. "But it kills larvae of the mosquito that spreads yellow fever and dengue fever in the tropical and subtropical regions of the world. There may be other FDA-approved drugs we didn't realize can also be insecticides."
The next steps to develop the genome-centric method are to explore other drugs through an in vivo assay to discover insecticidal or larvicidal properties and identify novel chemicals that affect the targeted receptor of disease-carrying insects. Hill and Watts also are looking to develop private-public partnerships to determine the most effective methods to deliver these insecticides.
Their genome-focused method to create new insecticides is patent-pending, and it is available for licensing through Vicky Montenegro, project manager for the Purdue Office of Technology Commercialization, at 765-588-3491, firstname.lastname@example.org. They received funding for their research from the U.S. Department of Defense and Purdue's Discovery Park Seed Grant Program.
About Purdue Office of Technology Commercialization
Purdue Office of Technology Commercialization operates one of the most comprehensive technology transfer programs among leading research universities in the United States. Services provided by this office support the economic development initiatives of Purdue University and benefit the university's academic activities.